Phenotypic profle of monocyte-macrophage lineage cells as a function of respiratory epithelium status

The mechanism of the relationship between pretumor changes in bronchial respiratory epithelium and risk progression non-small cell lung cancer (NSCLC) remains unclear. It has been suggested that reactive mucosa NSCLC may be caused by functional status monocytic-macrophage cells as important participants infammation, which determines both premalignant malignant progression. purpose study was to investigate phenotypic profle peripheral blood monocytes macrophages induced from vitro depending on state patients. Material Methods . included 39 patients with newly diagnosed NSCLC. Based morphological examination small bronchi taken at distance 3–5 cm tumor, were divided into following groups type changes: no (n=6), isolated basal hyperplasia (BCH) (n=13), combination BCH squamous metaplasia (SM) (n=3), unchanged focal (n=17). features -induced assessed before treatment using fow cytometry. Results prior start anticancer associated monocytes, but not them. Distortion response polarizing stimuli observed patients: cultured responded M1 M2 inducers (LPS IL-4, respectively) a phenotype shift M2, while CD206 marker expression varied presence changes. Conclusion anti-tumor treatment, macrophages.